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KMID : 0043320090320030399
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Archives of Pharmacal Research
2009 Volume.32 No. 3 p.399 ~ p.405
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Effects of Schisandrin on Transcriptional Factors in Lipopolysaccharide- Pretreated Macrophages
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Kim Yeong-Shik
Kim Hyun-Pyo
Kang Sam-Sik
Chung Ji-Won
Shin Eun-Myoung
Jang Se-Hyun
Bae Ki-Hwan
Hung Tran Manh
Guo Lian Yu
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Abstract
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Schisandrin is the main active ingredient isolated from Schisandra chinensis Baill. Recent studies have demonstrated that schisandrin exhibits anti-inflammatory effects in vivo and in vitro. In this study, we examined whether the order of lipopolysaccharide (LPS) treatment affects the mechanism of schisandrin anti-inflammatory activity. We found that the antiinflammatory mechanisms are not the same depending on whether macrophages were treated with schisandrin before or after LPS. The main difference is that inhibitor kappaBα (IκBα) degradation was not inhibited when macrophages were pretreated by LPS before schisandrin and was weakly inhibited when macrophages were pretreated by schisandrin before LPS.
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KEYWORD
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Schisandrin, Lipopolysaccharide, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, RAW 264.7 macrophage
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